Fasciclin 2 functions as an expression-level switch on EGFR to control organ shape and size in Drosophila.
Fasciclin 2 (Drosophila NCAM) is a homophilic Cell Adhesion Molecule expressed at moderate levels in the proliferating epithelial cells of imaginal discs, where it engages EGFR quick sling heater mount in a cell autonomous auto-stimulatory loop that promotes growth along larval development.In addition, Fasciclin 2 is expressed at high levels in the